PBPK Model Evaluation Checklist

A General Details
The reviewer can be considered as
A1. Context/Implementation:
1.1. Regulatory purpose:
A2. Documentation:
A3. Software Implementation and Verification:
A4. Peer engagement (input/review):
B. Assessment of Model Validity : B.1. Biological Basis (Model Structure and Parameters):
B.2. Theoretical Basis of Model Equations:
B.3. Reliability of input parameters:
B.4. Uncertainty and Sensitivity Analysis :
B.5. Goodness-of-Fit and Predictivity: For PBK models for which there are not sufficient in vivo data for the chemical of interest:
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PBPK Model Evaluation

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